鈥檚 stock price has jumped by more than 20% after all patients in a trial of its Parkinson鈥檚 disease vaccine-like immunotherapy responded to the target antigen.
On Thursday (14 November), the Switzerland-based pharma company saw its stock rise by 26.9% from market close on 13 November to the 14 November high. The stock rose following the announcement of positive interim data from the of its anti-alpha-synuclein (a-syn) active immunotherapy candidate ACI-7104.056.
Not only did the data show positive antibody responses against the target antigen at six weeks, but the responses were strongly boostable. a-syn is believed to be a key protein in the disease due to its high prevalence in patients with Parkinson’s disease.
Treatment with ACI-7104.056 induced an increase in anti-a-syn antibodies on average 16-fold higher than the placebo background level after three immunisations.
CEO of AC Immune, Dr. Andrea Pfeifer, said: 鈥淭he level of immunogenicity after only three months of treatment as well as the continued positive safety profile, reinforces the best-in-class characteristics of our clinically validated anti-a-syn active immunotherapy for the treatment of Parkinson鈥檚 disease.鈥�
VacSYn is an adaptive, placebo-controlled, and biomarker-based Phase II study in patients with early Parkinson鈥檚 disease, consisting of two parts with a seamless transition. Part 1 includes initial analyses from over 30 patients randomised to receive ACI-7104.56 or placebo at a ratio of 3:1. To date, no adverse events (AEs) have been reported other than transient injection site reactions (49%) and headaches (18%).
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By GlobalDataAC Immune plans to release further interim results in H1 2025 including pharmacodynamic data, after which it plans to initiate Part 2 of VacSYn with up to 150 patients. Patients in Part 2 will be evaluated for the progression of motor and non-motor symptoms of the disease, as well as digital, imaging, and fluid biomarkers.
After the second part of the study, the Swiss company hopes the data will support progression to a pivotal study.
According to GlobalData鈥檚 drug database, there are 93 pipeline products in Phase I to Phase III development within the 7MM for the treatment of Parkinson鈥檚 disease. Therapies targeting a-syn aggregation account for 26% of the pipeline disease-modifying therapies (DMTs).
GlobalData is the parent company of 污污漫畫 Technology.
At the AD/PD conference in March 2024, Vaxxinity announced positive data from a Phase I trial of its a-syn vaccine-like therapy, UB-312.
