WuXi will offer end-to-end support for the IMB1001 project. Credit: Lucas Vasques on Unsplash.

IMIDomics and WuXi Biologics have signed an agreement to advance of the humanised antibody IMB1001 for immune-mediated inflammatory diseases (IMIDs).

IMB1001 has been designed to target the transmembrane glycoprotein CD226.

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As part of the deal, WuXi will be responsible for delivering comprehensive chemistry manufacturing controls (CMC) development and current good manufacturing practice (cGMP) manufacturing services for the humanised antibody.

Leveraging its advanced facilities, technology and scientific team, WuXi will offer end-to-end support for the IMB1001 project.

It will be involved in analytical method establishment, process development, services related to CMC and cGMP manufacturing to be in line with regulatory standards.

IMIDomics used its technology and data sets to detect CD226 that is significantly upregulated during an inflammatory immune response.

IMB1001 can downregulate the pro-inflammatory cytokines production by blocking CD226 signalling.

The specific mechanism of action linked to the antibody has potentially wider applicability across several diseases.

IMIDomics leverages its multidimensional, integrated and data-driven platform, Discovery Engine, for identifying the underlying mechanisms of IMIDs.

IMIDomics chief development officer Daniel Perez said: 鈥淲uXi Biologics’ track record of excellence and expertise in biologics research, development and manufacturing aligns perfectly with our vision to bring transformative biologics therapies to IMID patients in need.

鈥淭his collaboration represents a significant milestone for IMIDomics as we advance IMB1001 towards clinical development.鈥�

Last month, IMIDomics signed an exclusive agreement to license TNAX Biopharma鈥檚 IMB1001.

Under the deal, IMIDomics obtained global rights for the development, production, marketing and sub-licensing of IMB1001 from TNAX.